Postdoc Neurosurgery

Functie inhoud

Job Description

Brain tumors, particularly glioblastoma, are among the most aggressive cancers, with no curative treatments currently available. Recent clinical trials investigating immunotherapy with oncolytic viruses (OVs) have shown promising results, although only a subset of patients achieve durable responses.

We aim to identify which tumor-, microenvironment-, or host-related factors influence response to OV therapy. To this end, we will develop and compare ex vivo model systems derived directly from patient tumor tissue and blood. These models will be evaluated in parallel with an upcoming clinical trial at our department that tests an oncolytic adenovirus, with the goal of determining their predictive value. In addition, trial-associated studies will map immune responses to OV treatment in patients.